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KMID : 1134120150180040323
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Journal of Breast Cancer
2015 Volume.18 No. 4 p.323 ~ p.328
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High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer
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Sim Jong-Min
Ahn Hye-In
Rehman Abdul
Kim Hyun-Sung
Yi Ki-Jong
Chung Yu-Min
Chung Min-Sung
Paik Seung-Sam
Song Young-Soo
Jang Ki-Seok
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Abstract
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Purpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied.
Methods: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome.
Results: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression.
Conclusion: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.
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KEYWORD
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Breast neoplasms, MicroRNA-370, Prognosis, Real-time polymerase chain reaction
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